Post doc position within the WASP-DDLS collaboration at the Department of Biochemistry and Biophysics, Stockholm University
This position is part of a joint collaboration between the two largest research programs in Sweden, the Wallenberg AI, Autonomous Systems and Software Program (WASP) and the SciLifeLab and Wallenberg National Program for Data-Driven Life Science (DDLS), with the ultimate goal of solving ground-breaking research questions across disciplines.
Cryo-electron microscopy (cryo-EM) has been a revolution for structural biology with its ability to computationally recover the 3D electron density of proteins based on millions of noisy images of single protein molecules. In some cases, modern reconstruction methods have also made it possible to predict flexibility of molecules, but only on coarse scales. This postdoctoral project is a collaboration with the math department at KTH, where we will use the massive amounts of data on protein motion available in molecular simulations produced in our team to develop new neural networks to provide data-driven priors of atomic models used to predict both structure and motion from new cryo-EM data we collect at SciLifeLab.