Background and aim
The present position, at the Department of Pharmacology, is one of two postdoctoral positions in a DDLS/WASP-funded joint research project between Pär Matsson (Department of Pharmacology, University of Gothenburg), and Alexander Schliep (CSE, University of Gothenburg | Chalmers), aiming to improve the design of oligonucleotide-based drugs using computational chemistry, biophysical simulation and AI methods. The two postdoctoral scientists will closely collaborate, will be jointly supervised by both PIs, and spend time in both labs. Close ties to the OligoNova Hub at the University of Gothenburg (part of SciLifeLab’s Drug Discovery and Development platform) and the considerable research activities at AstraZeneca R&D Gothenburg, provide a vibrant research environment in the exciting new area of computational design of oligonucleotide therapeutics.
Molecular simulation and computational chemistry of therapeutic oligonucleotides.
The postdoctor will develop and apply molecular dynamics simulation and quantum mechanics-based techniques to study the impact of chemical modification on the binding of therapeutic oligonucleotides to target nucleotide sequences and to cellular proteins.